Latest Article

Back Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease The vascular endothelium is a major regulator of vessel biology in health and disease. While the importance of the endothelium has long been recognized to be at...

Back ECs in health and disease Development vs. adulthood The vasculature forms early during embryo development and is essential for the growth, survival, and function of all organ systems. Its innermost layer, the endothelium, is a major regulator of vessel...

Back EndMT role in EC biology 3.1 EndMT process overview EndMT is a complex biological process characterized by profound morphological, molecular, and functional changes in EC phenotype.46–48 EndMT plays an integral role in embryonic development14,49,50 and was first described as a locally...

Back EC plasticity potential in EndMT: fate of EndMT-derived cells The multi-step cell fate changes observed in EndMT can be described as a continuum rather than a binary event.87,88 As such, this transition can eventually lead to mesenchymal-like cells where the...